بررسی ارتباط سطح سرمی منیزیم و تشنج ناشی از تب در کودکان

Background and purpose: Febrile seizure (FS) is the most common type of seizure in children which is triggered byvariety of causes. The aim of this study was to evaluate and compare the serum level of magnesium (Mg) in three groups: children with FS (A), febrile children without seizure (B) and normal children (C). Also, this study investigated the relationship between severity of fever and serum level of magnesium. Materials and methods: This case-control study included 94, 93, and 40 children in groups A, B, and C, respectively. The subjects aged between 6 months to 6 years. The serum magnesium levels were analyzed by atomic absorption spectrophotometer. T-test and Pearson correlation coefficient were applied to analyze the data. Results: The mean axillary temperatures were 38.8 ± 0.4 °C in group A and 38.4± 0.44 °C in group B. The mean levels of magnesium in groups A, B, and C were 15.66 ± 2.85, 14.61 ± 1.97, and 19.44 ± 1.86 mg/L, respectively. However, these levels significantly decreased in groups A and B when compared with normal children. Moreover, we found a significant negative correlation between the serum magnesium level in children with FS and severity of fever (r = -0.312, P<0.005(. Conclusion: Magnesium plays an important role in pathogenesis of febrile seizure. In fact, the increase of fever is correlated with the reduction in serum magnesium level in febrile children.